TABLE 1.

MICs and doses for breakthrough Candida bloodstream isolates

Candida sp.	Daily fluconazole dose (mg)	Cumulative fluconazole dose (mg)	MIC (μg/ml)	Daily dose/MIC ratio
C. albicans	50	250	1	50
C. parapsilosis	100	1,300	1	100
C. albicans	100	700	1	100
C. tropicalis	100	400	2	50
C. glabrata	100	1,200	2	50
C. glabrata	100	2,100	64	1.56
C. krusei	100	2,200	64	1.56
C. glabrata	100	2,400	64	1.56
C. parapsilosis	200	5,000	0.5	400
C. parapsilosis	200	2,200	1	200
C. albicans	200	1,400	1	200
C. albicans	200	2,400	1	200
C. parapsilosis	200	800	1	200
C. glabrata	200	1,800	2	100
C. tropicalis	200	13,200	4	50
C. parapsilosis	200	3,600	4	50
C. glabrata	200	2,400	16	12.5
C. lusitaniae	200	3,600	32	6.25
C. krusei	200	2,000	64	3.12
C. krusei	200	5,000	64	3.12
C. albicans	200	3,600	64	3.12
C. glabrata	200	600	64	3.12
C. tropicalis	200	2,800	128	1.56
C. glabrata	400	5,400	32	12.5
C. glabrata	400	2,400	32	12.5
C. krusei	400	4,400	64	6.25
C. albicans	400	7,200	128	3.12
C. glabrata	800	12,400	128	6.25