TABLE 1.
Pharmacokinetic parametersa of KOSN-2079 and KOSN-2089 in mouse plasma
| Compound and routeb | Dose (mg/kg) | Cmax (μg/ml) | Tmax (h) | AUC (μg/ml · h) | t1/2 (h) | Clearance (liters/h/kg) | Vss (liters/kg) | F | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| KOSN-2079
|
||||||||||||||||
| p.o. | 2.5 | 2.18 | 2.00 | 23.47 | 3.7 | 0.11 | 0.85 | 0.91 | ||||||||
| i.v. | 1.0 | 2.05 | 0.03 | 10.28 | 4.7 | 0.10 | 0.75 | |||||||||
| KOSN-2089
|
||||||||||||||||
| p.o. | 2.5 | 0.12 | 0.50 | 5.89 | 29.1 | 0.42 | 18.34 | 0.67 | ||||||||
| i.v. | 1.0 | 0.19 | 0.03 | 3.50 | 37.4 | 0.29 | 14.82 | |||||||||
a
Cmax, maximum concentration of drug in plasma; Tmax, time to maximum concentration of drug in plasma; AUC, area under the concentration-time curve; t1/2, half-life; Vss, volume of distribution at steady state.
b
p.o., oral (per os); i.v., intravenous.