TABLE 1.
Summary statistics for ATV pharmacokinetic parametersa
| Pharmacokinetic parameter | Result with regimen:
|
||||
|---|---|---|---|---|---|
| ATV 400 (day 6; n = 52) | ATV/RTV 300/100 (day 16; n = 48) | ATV/RTV/RIF 300/100/600 (day 26; n = 16) | ATV/RTV/RIF 300/200/600 (day 26; n = 17) | ATV/RTV/RIF 400/200/600 (day 26; n = 14) | |
| Geometric mean AUC(TAU) (ng · h/ml) (CV%) | 28,204.3 (38) | 44,517.1 (33) | 12,661.2 (33) | 20,691.2 (34) | 24,041.9 (35) |
| Geometric mean Cmax (ng/ml) (CV%) | 5,337.1 (24) | 5,135.7 (31) | 2,611.0 (33) | 3,342.2 (33) | 3,906.4 (30) |
| Geometric mean Cmin (ng/ml)b (CV%) | 186.9 (104) | 707.3 (58) | 18.1 (58) | 42.7 (81) | 52.9 (78) |
| Median Tmax (h) (min, max) | 2.0 (1, 4) | 2.5 (2, 4) | 2.8 (2, 4) | 2.5 (2, 4) | 2.5 (2, 4) |
| Mean T-half (h) (SD) | 6.3 (2.4) | NEc | 3.4 (0.7) | 3.2 (0.6) | 3.5 (0.8) |
a
BLQ values were replaced by 1/2LLQ = 2.5 ng/ml. Day 6, ATV 400; day 16, ATV/RTV 300/100; day 26, ATV/RTV/RIF 300/100/600, ATV/RTV/RIF 300/200/600, or ATV/RTV/RIF 400/200/600. n = number of subjects.
b
24 h postdose.
c
NE, not evaluated.