TABLE 3.
Summary statistics for RIF pharmacokinetic parametersa
| Pharmacokinetic parameter | Result with regimen:
|
|||
|---|---|---|---|---|
| ATV/RTV/RIF 300/100/600 (day 26; n = 16) | ATV/RTV/RIF 300/200/600 (day 26; n = 17) | ATV/RTV/RIF 400/200/600 (day 26; n = 14) | RIF 600 (day 26; n = 14) | |
| Geometric mean AUC(TAU) (ng · h/ml) (CV%) | 46,571.8 (36) | 49,483.9 (47) | 51,257.0 (21) | 31,267.7 (46) |
| Geometric mean Cmax (ng/ml) (CV%) | 10,613.1 (35) | 11,222.6 (37) | 10,983.3 (18) | 8,057.6 (45) |
| Geometric mean Cmin (ng/ml)b (CV%) | 25.0 (0) | 25.0 (0) | 25.0 (0) | 25.0 (0) |
| Median Tmax (h) (min, max) | 2.5 (2, 4) | 2.5 (2, 4) | 2.5 (2, 4) | 2.5 (2, 4) |
| Mean T-half (h) (SD) | 1.6 (0.2) | 1.7 (0.5) | 1.7 (0.4) | 1.5 (0.2) |
a
BLQ values were replaced by 1/2LLQ = 25 ng/ml. Day 26, ATV/RTV/RIF 300/100/600, ATV/RTV/RIF 300/200/600, or ATV/RTV/RIF 400/200/600; day 26, RIF 600. n = number of subjects.
b
24 h postdose.