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. 2006 Oct;50(10):3297–3304. doi: 10.1128/AAC.00251-06

FIG. 3.

FIG. 3.

Stimulation of vanadate-sensitive ATPase activity in isolated insect membranes overexpressing Pgp or MRP2 by known substrates and TFV. While verapamil was able to markedly increase the amount of vanadate-sensitive ATPase activity, TFV at a concentration of 1,000 μM was unable to stimulate ATP hydrolysis by Pgp-overexpressing membranes (A). While probenecid caused a marked increase in the amount of vanadate-sensitive ATPase activity, TFV at a concentration of 1,000 μM was unable to stimulate ATP hydrolysis by MRP2-overexpressing membranes (B). Values represent the mean ± standard deviation of at least two independent experiments done in duplicate.