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Effect of MRP2 expression on cytotoxicity of vinblastine and TFV in MDCKII cells
| Compound | CC50 (μM)
|
Fold changea | |
|---|---|---|---|
| Wild type | MRP2 | ||
| Vinblastine | 0.0039 ± 0.0014 | 0.012 ± 0.004 | 2.9b |
| TFV | 17,600 ± 1,000 | 11,700 ± 500 | 0.7 |
Values represent the mean ± standard deviation of three independent experiments done in triplicate.
Significant (P < 0.05) decrease in toxicity due to MRP2 expression based on Student's unpaired two-tailed t test assuming equal variance.
