TABLE 2.
Cytotoxicities of adefovir, TFV, and TDF (oral prodrug of TFV) in parental (CEM-SS) and MRP4-overexpressing (CEM-R1) cells
| Compound | CC50 (μM)
|
Fold changea | |
|---|---|---|---|
| CEM-SS | CEM-R1 | ||
| Adefovir | 2,100 ± 283 | >20,000 | >9.5 |
| TFV | 5,933 ± 814 | 12,030 ± 1,060 | 2.0b |
| TDF | 40 ± 14 | 101 ± 11 | 2.5c |
a
Values represent the mean ± standard deviation of three (TFV) or four (TDF) independent experiments performed in triplicate.
b
Significant (P < 0.01) decrease in toxicity due to MRP4 expression based on Student's unpaired two-tailed t test assuming equal variance.
c
Significant (P < 0.001) decrease in toxicity due to MRP4 expression based on Student's unpaired two-tailed t test assuming equal variance.