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. 2006 Oct;50(10):3464–3466. doi: 10.1128/AAC.00558-06

FIG. 2.

FIG. 2.

Antifungal activity of KOSN-2079 in the mouse model of pulmonary aspergillosis. (A) Groups of eight mice were infected with A. fumigatus strain Af293 and treated with the indicated drugs for 4 days, starting on the day after infection. Pulmonary fungal burdens were determined 1 day after the last dose of drug. Results are medians ± interquartile ranges from one experiment. *, P < 0.001 for comparison to the vehicle control group by the Wilcoxon rank sum test. (B) Survival of mice infected with A. fumigatus and treated with the indicated drugs (16 mice per group) for 7 days, starting on the day after infection. The dose of KOSN-2079 was 200 mg/kg/day, and the dose of amphotericin B was 3 mg/kg/day. *, P < 0.0001 for comparison to the vehicle control group by the log rank test. §, P = 0.02 for comparison to mice treated with KOSN-2079. Abbreviations: 2079, KOSN-2079; Ampho B, amphotericin B.