FIG. 2.

Effects of PA-824 and rifampin on the multiplication of M. leprae in BALB/c and nude mice. The drugs were given orally in a CM-2 formulation for 4 weeks during the third month. (A) Growth kinetics of M. leprae in BALB/c mice. The drug treatment and harvest time points are indicated by arrows. (B) AFB counts were measured at the plateau and 4 weeks later in all groups (n = 5) of BALB/c mice. Drugs were administered at 8, 100, and 25 mg/kg as indicated in the key. (C) AFB counts measured 6 months postinfection in the nude mouse model (n = 5). (D) Photographs of drug-treated nude mouse footpads before harvest. FP, footpad; RMP, rifampin; P, plateau in AFB growth; W, weeks.