Abstract
The linoleic acid content of serum lipids was measured in 47 patients with multiple sclerosis, 29 patients with other neurological diseases, 35 patients with acute non-neurological illnesses, and 49 healthy control subjects. Reduced linoleic acid content of serum lipids was not specific to multiple sclerosis and occurred in all ill patients with acute non-neurological illness. The fatty-acid pattern of serum lipids in illness resembles that of essential fatty-acid deficiency. It seems that this pattern of reduced linoleic acid content with increased oleic, palmitic, and palmitoleic acid content may be a general phenomenon in ill patients.
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Selected References
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- AAES-JORGENSEN E. Essential fatty acids. Physiol Rev. 1961 Jan;41:1–51. doi: 10.1152/physrev.1961.41.1.1. [DOI] [PubMed] [Google Scholar]
- ALLMANN D. W., GIBSON D. M. FATTY ACID SYNTHESIS DURING EARLY LINOLEIC ACID DEFICIENCY IN THE MOUSE. J Lipid Res. 1965 Jan;6:51–62. [PubMed] [Google Scholar]
- ALLMANN D. W., HUBBARD D. D., GIBSON D. M. FATTY ACID SYNTHESIS DURING FAT-FREE REFEEDING OF STARVED RATS. J Lipid Res. 1965 Jan;6:63–74. [PubMed] [Google Scholar]
- Alling C., Vanier M. T., Svennerholm L. Lipid alterations in apparently normal white matter in multiple sclerosis. Brain Res. 1971 Dec 24;35(2):325–336. doi: 10.1016/0006-8993(71)90478-1. [DOI] [PubMed] [Google Scholar]
- Arnetoli G., Pazzagli A., Amaducci L. Fatty acid and aldehyde changes in choline- and ethanolamine-containing phospholipids in the white matter of multiple sclerosis brains. J Neurochem. 1969 Mar;16(3):461–463. doi: 10.1111/j.1471-4159.1969.tb10387.x. [DOI] [PubMed] [Google Scholar]
- BAKER R. W., SANDERS H., THOMPSON R. H., ZILKHA K. J. SERUM CHOLESTEROL LINOLEATE LEVELS IN MULTIPLE SCLEROSIS. J Neurol Neurosurg Psychiatry. 1965 Jun;28:212–217. doi: 10.1136/jnnp.28.3.212. [DOI] [PMC free article] [PubMed] [Google Scholar]
- BAKER R. W., THOMPSON R. H., ZILKHA K. J. Fatty-acid composition of brain lecithins in multiple sclerosis. Lancet. 1963 Jan 5;1(7271):26–27. doi: 10.1016/s0140-6736(63)91152-8. [DOI] [PubMed] [Google Scholar]
- BAKER R. W., THOMPSON R. H., ZILKHA K. J. SERUM FATTY ACIDS IN MULTIPLE SCLEROSIS. J Neurol Neurosurg Psychiatry. 1964 Oct;27:408–414. doi: 10.1136/jnnp.27.5.408. [DOI] [PMC free article] [PubMed] [Google Scholar]
- CARR J. J., DREKTER I. J. Simplified rapid technic for the extraction and determination of serum cholesterol without saponification. Clin Chem. 1956 Oct;2(5):353–368. [PubMed] [Google Scholar]
- COMBES M. A., PRATT E. L., WIESE H. F. Essential fatty acids in premature infant feeding. Pediatrics. 1962 Jul;30:136–144. [PubMed] [Google Scholar]
- Callaghan N., Kearney B., Love W. C. Dietary intake of linoleic acid in multiple sclerosis and other diseases. J Neurol Neurosurg Psychiatry. 1973 Aug;36(4):668–673. doi: 10.1136/jnnp.36.4.668. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Clausen J., Hansen I. B. Myelin constituents of human central nervous system. Acta Neurol Scand. 1970;46(1):1–17. doi: 10.1111/j.1600-0404.1970.tb05601.x. [DOI] [PubMed] [Google Scholar]
- Collins F. D., Sinclair A. J., Royle J. P., Coats D. A., Maynard A. T., Leonard R. F. Plasma lipids in human linoleic acid deficiency. Nutr Metab. 1971;13(3):150–167. doi: 10.1159/000175332. [DOI] [PubMed] [Google Scholar]
- Cumings J. N., Shortman R. C., Skrbic T. Lipid studies in the blood and brain in multiple sclerosis and motor neurone disease. J Clin Pathol. 1965 Sep;18(5):641–644. doi: 10.1136/jcp.18.5.641. [DOI] [PMC free article] [PubMed] [Google Scholar]
- GERSTL B., KAHNKE M. J., SMITH J. K., TAVASTSTJERNA M. G., HAYMAN R. B. Brain lipids in multiple sclerosis and other diseases. Brain. 1961 Jun;84:310–319. doi: 10.1093/brain/84.2.310. [DOI] [PubMed] [Google Scholar]
- Gerstl B., Eng L. F., Tavaststjerna M., Smith J. K., Kruse S. L. Lipids and proteins in multiple sclerosis white matter. J Neurochem. 1970 May;17(5):677–689. doi: 10.1111/j.1471-4159.1970.tb00547.x. [DOI] [PubMed] [Google Scholar]
- Gul S., Smith A. D., Thompson R. H., Wright H. P., Zilkha K. J. Fatty acid composition of phospholipids from platelets and erythrocytes in multiple sclerosis. J Neurol Neurosurg Psychiatry. 1970 Aug;33(4):506–510. doi: 10.1136/jnnp.33.4.506. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HOLMAN R. T. The ratio of trienoic: tetraenoic acids in tissue lipids as a measure of essential fatty acid requirement. J Nutr. 1960 Mar;70:405–410. doi: 10.1093/jn/70.3.405. [DOI] [PubMed] [Google Scholar]
- Harvey R. F. Serum-thyroxine and thyroxine-binding globulin in seriously ill patients. Lancet. 1971 Jan 30;1(7692):208–212. doi: 10.1016/s0140-6736(71)90950-0. [DOI] [PubMed] [Google Scholar]
- Jurand J., Oliver M. F. Effects of acute myocardial infarction and of noradrenaline infusion on fatty acid composition of serum lipids. Atherosclerosis. 1970 Jan-Feb;11(1):157–170. doi: 10.1016/0021-9150(70)90013-4. [DOI] [PubMed] [Google Scholar]
- Kirkeby K., Bjerkedal I. Concentrations and fatty acid composition of serum lipid fractions following ACTH in rabbits. Acta Med Scand. 1972 Dec;192(6):529–533. doi: 10.1111/j.0954-6820.1972.tb04861.x. [DOI] [PubMed] [Google Scholar]
- Kirkeby K. Disturbances in serum lipids and in their fatty acid composition following acute myocardial infarction. Acta Med Scand. 1972 Dec;192(6):523–528. doi: 10.1111/j.0954-6820.1972.tb04860.x. [DOI] [PubMed] [Google Scholar]
- Kirkeby K., Ingvaldsen P., Bjerkedal I. Fatty acid composition of serum lipids in men with myocardial infarction. Acta Med Scand. 1972 Dec;192(6):513–519. doi: 10.1111/j.0954-6820.1972.tb04857.x. [DOI] [PubMed] [Google Scholar]
- Millar J. H., Zilkha K. J., Langman M. J., Wright H. P., Smith A. D., Belin J., Thompson R. H. Double-blind trial of linoleate supplementation of the diet in multiple sclerosis. Br Med J. 1973 Mar 31;1(5856):765–768. doi: 10.1136/bmj.1.5856.765. [DOI] [PMC free article] [PubMed] [Google Scholar]
- SCOTT R. F., LIKIMANI J. C., MORRISON E. S., THUKU J. J., THOMAS W. A. ESTERIFIED SERUM FATTY ACIDS IN SUBJECTS EATING HIGH AND LOW CHOLESTEROL DIETS. A COMPARATIVE STUDY OF SERUM LIPID METABOLISM IN NEW YORKERS, INDIGENOUS POOR EAST AFRICANS AND UPPER CLASS EAST AFRICANS. Am J Clin Nutr. 1963 Aug;13:82–91. doi: 10.1093/ajcn/13.2.82. [DOI] [PubMed] [Google Scholar]
- Tichý J., Vymazal J., Michalec C. Serum lipoproteins, cholesterol esters and phospholipids in multiple sclerosis. Acta Neurol Scand. 1969;45(1):32–40. doi: 10.1111/j.1600-0404.1969.tb01217.x. [DOI] [PubMed] [Google Scholar]
- VALTNERE A. L. O funktsional'nom sostoianii shchitovidnoi zhelezy u bol'nykh rasseiannym sklerozom. Zh Nevropatol Psikhiatr Im S S Korsakova. 1959;59(5):523–524. [PubMed] [Google Scholar]
- ZOELLNER N., WOLFRAM G. [On the composition of cholesterol esters in several liver diseases]. Klin Wochenschr. 1961 Aug 1;39:817–818. doi: 10.1007/BF01482106. [DOI] [PubMed] [Google Scholar]
