Figure 8.

Kaplan-Meier survival curves are shown relating PGIS immunohistochemical staining to patient survival time (months) from the tissue microarray. Analysis for all NSCLC regardless of tumor type (total number = 110 samples), was completed (PGIS-negative = 94; PGIS-positive = 14; 2 not scoreable). Cox regression model was used to examine the association between positive PGIS staining and survival after adjusting for age, gender, and tumor stage. Survival was significantly correlated to positive PGIS staining using log-rank test (χ² = 3.942, P value = 0.047) and gave a hazard ratio = 0.20 (95% CI = 0.027 to 1.51, P value = 0.119). The lack of significance in the hazard ratio is probably a function of the small number of deaths in the positive PGIS staining group relative to the amount of follow-up and variability in time to death.