Table 2.
Genes Recently Identified as Potential Biomarkers in Human Cancers
| Name | Gene symbol | Human | Murine | Reference |
|---|---|---|---|---|
| Caveolin 1 | CAV1 | ↓ | ↓ | 55 |
| Claudin 3 | CLDN3 | ↑ | ↑ | 44** |
| Matrix metalloproteinase 12 | MMP12 | ↑ | ↑ | 56 |
| Melanoma antigen, family D1* | MAGED1 | ↑ | ↑ | 43 |
| Osteopontin (secreted phosphoprotein 1) | SPP1 | ↑ | ↑ | 57 |
Gene expression changes are shown for five previously reported potential biomarkers, as designated in Table 1. The single asterisk refers to MAGED1, which has not been reported as a biomarker but is a member of MAGE gene family, which has been reported as a biomarker for numerous cancer types. CLDN3 has not been reported as a biomarker for lung cancer (indicated by the double asterisks) but has been reported as a biomarker and potential therapeutic target in ovarian cancer.