Table 1.

Experimental Design

MIF	Systemic estrogen*
	−	+
−	OVX, KO	INT, KO
	(Three mice)	(Three mice)
+	OVX, WT	INT, WT
	(Three mice)	(Three mice)

^*Nonovariectomized mice have intact (INT) ovaries. Hereafter, the INT, KO and INT, WT conditions will be referred to as KO and WT.