FIG. 1.

(A) Structures of Rat MFE2 and Dictyostelium MFE1. Rat MFE2 consists of three domains, as do other mammalian MFE2/DBPs, while Dictyostelium MFE1 consists of two domains, also found in the C. elegans counterpart. The ECH domain exists as a distinct protein MFE2. (B and C) Comparison in amino acid sequence of the HCD domain (B) and SCP2 domain (C) among Dictyostelium MFE1 (accession number: BAA94961) and worm, rat, and human counterparts (accession numbers T16638, NP077368, and P51659, respectively) by using the MegAlign program of DNASTAR.