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. 2003 Jun;2(3):422–430. doi: 10.1128/EC.2.3.422-430.2003

FIG. 1.

FIG. 1.

Calcineurin is essential for the virulence of C. albicans. The wild-type strain CAF2 (diamonds), the cnb1/cnb1 calcineurin B mutants JRB64 (squares) and JRB71 (triangles), and the cnb1/cnb1+ CNB1 calcineurin B reconstituted strain MCC85 (multiplication signs) were used to infect groups of 5 (A) or 10 (B) mice each by lateral tail vein injection, and survival was monitored over time. The survival of mice infected with calcineurin mutant strains was significantly different from that of mice infected with the wild-type strain or the reconstituted mutant strain (P < 0.05), except between JRB64 and MCC85 in panel A. No significant difference was noted between the two calcineurin mutant strains or between the wild-type and reconstituted strains in either experiment (P > 0.05).