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. 2004 Mar;164(3):883–892. doi: 10.1016/S0002-9440(10)63176-8

Figure 5.

Figure 5

CNS lesions in C57BL/6J and H2RKO mice with EAE elicited by immunization with MOG35-55. Brain sections from H2RKO (A) and C57BL/6J mice (B) and spinal cord sections from H2RKO (C) and C57BL/6J mice (D) have principally a mononuclear inflammatory response associated with demyelination. In addition, the H2RKO mice (A, C) have numerous eosinophils (arrows) in the inflammatory response when compared to C57BL/6J mice (B, D). Brain and spinal cord sections from complete Freund’s adjuvant-immunized H2RKO control mice (E, F) and complete Freund’s adjuvant-immunized C57BL/6J control mice (G, H) have rare mononuclear inflammatory cell infiltrates perivascularly (E, arrow) and in the meninges and submeningeal white matter (H, arrow). H&E stains. Scale bar, 50 μm (A–H).