Figure 4.

Muscle and kidney histopathology in WT and in CD4C/HIV transgenic mice at disease stage Tg1 and Tg3. A, C, and E: H&E staining of 5-μm soleus transversal sections from WT, Tg1, and Tg3 CD4C/HIV animals, respectively. Mononuclear cell infiltrate is only observed in diseased animals (Tg3) whereas muscle sections are similar in WT and CD4C/HIV Tg1 animals. Representative pictures are shown (×40). B, D, and F: H&E staining of WT, Tg1, and Tg3 CD4C/HIV kidney sections. Severe kidney damage is already detected in young transgenic animals (Tg1) (×20). G: Higher magnification of Tg3 soleus muscle section revealing the presence of numerous infiltrating cells (×60) and (H), immunostaining with an anti-CD45 antibody of Tg3 kidney sections revealing the presence of infiltrating leukocytes (×20). Samples were analyzed in a blinded manner by two examiners (A.H. and Y.S.)