Table 1.

Transplant Vasculopathy Develops in Male but Not Female C3H Hearts Transplanted into Female Marilyn Recipients

Transplanted heart	Day harvested after transplant	Number of vessels with NI > 10%	Cumulative NI
C3H male	59	8/10	46%
C3H male	61	8/12	39%
C3H male	69	14/21	28%
C3H male	62	18/20	55%
C3H male	61	5/16	12.5%
C3H female	65	1/7	6%
C3H female	76	1/8	6%
C3H female	56	0/12	< 5%

Two to three elastin-stained sections of each heart graft were analyzed by computer-assisted image analysis for both the number of vessels with neointimal index (NI) of > 10% and the cumulative score for all vessels computed as outlined in Materials and Methods. Both the numbers of involved vessels and the overall NI were significantly greater in the male versus the female heart grafts (P < 0.05).