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. 2004 Jun;164(6):2163–2174. doi: 10.1016/s0002-9440(10)63774-1

Figure 9.

Figure 9

Nissl staining (cresyl violet) at 2 and 8 weeks after Aβ fibril and Aβ-AChE complex injections. Nissl stained coronal sections through dorsal hippocampus near to the injection site (*) (intact animal A) in bilaterally injected rats with ACF+DMSO (control). DG indicates the dentate gyrus and CA3 indicates the region of the Ammon horn of the hippocampus (B), Aβ fibrils assembled alone after 2 (C) and 8 weeks (E), and Aβ-AChE complexes after 2 (D) and 8 weeks (F). Note the extensive neuronal degeneration in animals injected with Aβ-AChE complexes after 8 weeks. G: Pictures (×40) of Nissl-stained sections were submitted to quantification of the neuron number. As observed in the graph, only Aβ-AChE complexes after 8 weeks of treatment induced a significant neuronal cell loss in the upper leaf of the dentate gyrus. *, P > 0.05 (Student’s t-test). Scale bars, 100 μm.