Figure 2.

Renal TNF and IL-1β levels were measured in WT and chimeric mice with GN. Kidney samples were homogenized and protein extracted, results expressed as concentration (ng) per tissue wet weight (g). A: Kidney TNF expression was significantly reduced in IL-1β^−/−→WT and WT→IL-1RI^−/− chimeric mice compared to WT mice (*, P < 0.05). B: Renal IL-1β expression was reduced in IL-1β^−/−→WT chimeras compared to WT→IL-1β^−/− chimeras (•, P < 0.05).