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. 2004 Jun;164(6):1967–1977. doi: 10.1016/s0002-9440(10)63757-1

Figure 4.

Figure 4

Histological features of glomerular injury in WT and IL-1β chimeric mice with GN: glomerular crescent formation, glomerular CD4+ T cell accumulation, and glomerular macrophage accumulation. Control WT mice with GN developed severe GN with a high incidence of glomerular crescent formation. In contrast IL-1β−/−→WT chimeric mice had a significant reduction in the proportion of glomeruli affected. WT→IL-1β−/− chimeric mice had a similar incidence of crescent formation to WT controls, which was significantly higher than IL-1β−/−→WT chimeric mice. Glomerular accumulation of CD4+ T cells and macrophages was significantly reduced in both chimeric groups, with a trend to a greater reduction observed in IL-1β−/−→WT chimeras because inflammatory cellular infiltrate is significantly reduced compared to WT→IL-1β−/− chimeras.