Figure 5.

Functional indices of injury in IL-1β chimeric mice with GN. WT mice with GN developed significant proteinuria, whereas IL-1β chimeric mice had reduced proteinuria compared with WT mice. Elevated serum creatinine demonstrated impaired renal function in WT and WT→IL-β^−/− chimeric mice, whereas significantly lower serum creatinine levels were demonstrated in IL-1β^−/−→WT chimeric mice. The dotted line indicates the urinary protein excretion and serum creatinine of normal WT mice without GN.