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Expression of underphosphorylated Rb in ALCL tumors. A: An ALK-positive ALCL case positive for underphosphorylated Rb in a small number (<10%) of tumor cells. Intensity of underphosphorylated Rb immunostaining was generally weaker compared with total Rb. B: An ALK-positive ALCL case negative for underphosphorylated Rb. Occasional small reactive lymphocytes show nuclear immunoreactivity and are considered as internal positive controls. DAB, hematoxylin counterstain, for all panels.
