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. 2004 Jun;164(6):2259–2267. doi: 10.1016/S0002-9440(10)63782-0

Figure 5.

Figure 5

FISH analysis for allelic loss at the rb locus using the Spectrum Orange LSI 13/RB-1 probe (Vysis). A: An ALK-positive ALCL case with most tumor cells showing two signals indicating the presence of both rb alleles. B: An ALK-negative ALCL case with hemizygous allelic loss of rb. Most tumor nuclei show a single signal indicated by arrows. Inset: Small reactive lymphocytes present in all tumor samples show two distinct signals for rb gene locus. C: An ALK-positive ALCL case with deletion of the rb locus. The red and green signals indicate the RB1 and centromeric (chromosome 8) probes, respectively.