Figure 4.
Genistein blocks If in a voltage independent way. (a) The If current was elicited by hyperpolarizing pulses to the voltages indicated and genistein (50 μM) was applied only after steady-state activation was reached. Evaluation of steady-state blocks yielded values of 28.5, 29.4, and 27.8% for currents recorded at −85, −105, and −125 mV, respectively. (b) Mean±s.e.m.% block obtained at different voltages (−75, −85, −105, and −125 mV) are plotted against voltage; statistical analysis did not reveal any voltage dependence of the block.