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Effects of angiotensin II on PV spontaneous activity. (a) The tracings and time course show an example that angiotensin II (10 and 100 nM) increased the PV spontaneous activity. The action potentials without a significant phase 4 depolarization suggested that these recordings were not directly from the cardiomyocytes with pacemaker activity. (b) The concentration–response curve of angiotensin II's effect on the automatic rhythm (n=7). *P<0.05, **P<0.01 versus before drugs.
