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Effect of losartan on the PV electrical activity. (a) The tracings and time course show an example that losartan (1 and 10 μM) decreased the PV spontaneous activity. (b) The superimposed tracings and time courses of the effects of losartan (1 and 10 μM) on the AP duration and contractile force. (c) The concentration–response curve for losartan's effect on the automatic rhythm (n=7), APD90, and contractile force (n=7). *P<0.05, **P<0.01, ***P<0.001 versus before drugs.
