Figure 5.

Effect of angiotensin II and losartan on I_to in PV cardiomyocytes. (a and b) Current traces, time course, and the I–V relationship (lower panels) of I_to before and after angiotensin II administration in PV cardiomyocytes with (n=7) and without (n=8) pacemaker activity. (c and d) Traces, time course, and the I–V relationship before and after the administration of losartan in PV cardiomyocytes with (n=8) and without (n=13) pacemaker activity. ^*P<0.05, ^**P<0.01, ^***P<0.001 versus before drugs. The insets in the current traces show the various clamp protocols.