Figure 7.

Effect of angiotensin II and losartan on I_K1 in PV cardiomyocytes. (a and b) Current traces and the I–V relationship (lower panels) of I_K1 before and after the administration of angiotensin II in PV cardiomyocytes with (n=7) and without (n=6) pacemaker activity. (c and d) Traces and the I–V relationship before and after losartan in PV cardiomyocytes with (n=6) and without (n=6) pacemaker activity. The insets in the current traces show the various clamp protocols. ^*P<0.05, ^**P<0.01, ^***P<0.001 versus before drugs.