Figure 8.
Effect of angiotensin II and losartan on If and Iti in PV cardiomyocytes. (a) The I–V relationship of If before and after the administration of angiotensin II in PV cardiomyocytes with (n=14) and without (n=17) pacemaker activity. (b) Superimposed current traces before and after the administration of angiotensin II. (c) The I–V relationship of If before and after the administration of losartan in PV cardiomyocytes with (n=8) and without (n=10) pacemaker activity. (d) There was a similar amplitude of If before and after the administration of losartan. (e and f) Angiotensin II increased Iti and losartan decreased Iti. The insets in the current traces show the clamp protocols. *P<0.05 versus before drugs. (g) The administration of BAPTA-AM (50 μM) reduces the inward currents in the PV cardiomyocytes confirms that this inward current on repolarization represents Iti.