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. 2005 Dec 5;147(2):140–157. doi: 10.1038/sj.bjp.0706497

Figure 4.

Figure 4

Representative tracings showing the response to prucalopride (a, b) and tegaserod (c) in porcine left atrial pectinate muscles. The effect caused by the administration of a single concentration of prucalopride in the absence (a) or presence (b) of 20 μM IBMX is shown. In (c) the biphasic effect caused by a single concentration, in the absence of IBMX, of tegaserod is demonstrated. The effect of the administration of GR113808 (0.1 μM), still in the presence of the agonist, is shown in (a–c). Experiments were terminated by the administration of a supramaximal concentration of isoprenaline (0.1 mM), still in the presence of previously administered substances.