Table 4.

Multivariant analysis of the TMA study set

a. Cox's proportional hazard analysis in stage I to IV patients
Variables	Risk ratio (95% confidence interval)	p
Age (≥65y)	1.618(0.944–2.774)	0.080
Gender (male)	0.615(0.365–1.036)	0.068
Lymph node metastasis (N1,2)	3.952(2.276–6.861)	<0.001*
Distant metastasis (M1)	1.720(0.938–3.155)	0.797
Tumor location (distal)	1.039(0.593–1.820)	0.894
Fascin (high)	1.184(0.905–3.676)	0.925
b. Cox's proportional hazard analysis in stage III and IV patients
Age (≥65y)	1.259(0.683–2.318)	0.460
Gender (male)	0.603(0.322–1.129)	0.114
Lymph node metastasis (N1,2)	0.969(0.336–2.791)	0.934
Distant metastasis (M1)	1.245(0.539–2.628)	0.566
Tumor location (distal)	1.464(0.776–2.765)	0.240
Fascin (high)	2.301(1.045–5.068)	0.039*