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. 2006 Oct 13;399(Pt 3):493–501. doi: 10.1042/BJ20051628

Figure 8. Effect of Ras inhibition on the activation of ERK1/2 by sustained intracellular acidosis in ARVM.

Figure 8

(A) Western blot of phosphorylated ERK1/2 (pERK1/2) in control cells or following sustained intracellular acidosis 42 h after infection with control adenovirus (empty virus) or N17-Ras (dn-Ras virus), and quantitative data from six separate experiments. Data are expressed as fold phosphorylation normalized to empty virus control. (B) Western blot of phosphorylated ERK1/2 (pERK1/2) in control cells or following sustained intracellular acidosis in the absence (vehicle) or presence of 50 μM FPT III, and quantitative data from six separate experiments. Data are expressed as fold phosphorylation normalized to vehicle control. *P<0.05 compared with control.