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Ribbon diagrams of active PAI-114–1B (a stable active PAI-1 variant carrying four mutations [42], PDB code 1DVM [43]), latent PAI-1 (PDB code 1LJ5), and the complex between the serpin α1-proteinase inhibitor and the protease elastase (PDB code 2D26 [6]). For the serpins, the RCL is in red, the large serpin fragment is in orange, the small serpin fragment including hF is in blue and hD and hE from the flexible joint region are in green. Elastase is shown in purple.
