Figure 4. Docking of paionin-1 into the structure of latent PAI-1 and residues important for paionin-1 binding in the flexible joint region.

Latent PAI-1 shown as a ribbon diagram with the inserted RCL in red, the large serpin fragment in orange, the small serpin fragment including hF in blue and hD and hE from the flexible joint region in green. (A) The docked structure of paionin-1 from conformational group number 1 is shown as a stick model. (B) Residues which based on binding assays with mutated PAI-1 variants are implicated in paionin-1 binding are indicated.