Figure 7. Relationship between autoxidation rates and p50 or oxygen dissociation rate constants.

Upper panel: relationship between the apparent k_ox and Hb–O₂ affinity (p50, i.e. the pO₂ at which half of Hb is saturated with oxygen) in various Hb types from the present study and from the literature [7]. The line represents the best linear fit when the point referring to MP4 is excluded from the calculation, with the 95% confidence limits, slope=(0.808±0.085)×10⁻³, intercept=(1.46±2.928)×10⁻³, P=0.0007. Lower panel: relationship between k_ox and the rate constant of oxygen dissociation from OxyHb in various Hb types from the literature [34,37]. The line represents the best linear fit when considering all data points, with the 95% confidence limits, slope=(0.648±0.141)×10⁻³, intercept=(−2.807±4.331)×10⁻³, P=0.04.