Figure 4. Plasma concentrations of APAP (A), APAP-glucuronide (B) and APAP-cysteine (C) in WT and SOD1^−/− mice treated with 600 mg of APAP/kg at various time points.

Mice were killed at 15, 30, 60, 120, 180 and 300 min after the APAP injection. There was no background in the PBS-treated mice. Values are means±S.E.M. (n=4–6); ‘#’ indicates the genotype effect (P<0.05) within the same time-point.