Table 1. Effect of genotype and APAP on hepatic enzyme activities.

Mice were treated with PBS or APAP (600 mg/kg) for 5 h. Values are means±S.E.M. (n=6–10).

	WT		SOD1−/−
Substrate	PBS	APAP	PBS	APAP
Total SOD	1384±55	1154±48*	15.6±0.8†	15.7±0.8†
(50% Formazan dye
formation rate inhibition
per mg of protein)
SOD2	12.5±0.15	11.0±1.0	12.0±0.25	10.9±0.55
(50% Formazan dye
formation rate inhibition
per mg of protein)
GPX1	862±34	652±40*	527±15†	414±39†
(Nanomoles of
glutathione oxidized per
min per mg of protein)
Thioredoxin reductase	27.2±0.97	10.0±0.79*	36.9±1.22†	14.1±1.53*
(Nanomoles of
5′-thionitrobenzoic acid
formed per min per
mg of protein)
Glutathione reductase	36.3±2.3	28.5±1.7	38.0±1.4	35.3±1.4
(Nanomoles of GSSG
reduced per min
per mg of protein)
GST	3926±188	2176±460*	4577±493	5318±118†
(Nanomoles of S-2,4-
dinitrophenylglutathione
formed per min per mg
of protein)

*The APAP-treatment effect (P<0.05) as compared with PBS treatment within genotypes.

†The genotype effect (P<0.05) within the same treatment.