Table 1. Physiological and EPR parameters following 20% transfusion with Hb–DBBF.
Time (min after transfusion) | ||||||||
---|---|---|---|---|---|---|---|---|
Parameter | Pre-transfusion control | 5 | 15 | 30 | 60 | 120 | 180 | |
MAP (mm Hg) | +DBBF | 80.8±11.9 | 93.8±9.2* | 91.7±10.7 | 98.0±13.0† | 94.4±9.1† | 88.1±12.7 | 92.3±7.7† |
Control | 80.1±12.9 | 81.1±11.5 | 75.5±13.5 | 78.3±12.8 | 73.3±8.8 | 71.9±10.5 | 70.4±9.9 | |
Heart rate (bpm) | +DBBF | 264.2±21.5 | 234.2±30.4* | 219.2±41.5 | 232.5±32.0 | 233.3±22.3 | 226.0±35.8 | 240.0±34.5 |
Control | 249.3±25.2 | 246.7±25.2 | 248.3±27.3 | 245.0±32.7 | 237.5±25.6 | 241.4±26.1 | 229.3±28.2 | |
Blood pH | +DBBF | 7.38±0.04 | 7.40±0.03 | 7.40±0.04 | 7.40±0.04 | 7.41±0.05 | 7.42±0.03 | 7.43±0.04 |
Control | 7.37±0.06 | 7.39±0.03 | 7.39±0.02 | 7.39±0.03 | 7.39±0.03 | 7.38±0.02 | 7.40±0.03 | |
Haematocrit | +DBBF | 40.9±3.6 | 31.5±3.6* | 30.9±3.6† | 30.5±3.2† | 31.0±3.5† | 29.8±3.0† | 29.7±3.0† |
Control | 37.6±3.0 | 36.6±2.8 | 37.0±2.3 | 36.7±2.2 | 37.0±1.9 | 35.0±2.2 | 35.0±2.4 | |
Total Hb (g/dl) | +DBBF | 12.5±1.7 | 11.1±1.0* | 10.9±1.2 | 11.0±1.2 | 11.1±1.3 | 10.7±1.0 | 10.5±0.5 |
Control | 11.9±0.9 | 11.4±0.6 | 11.7±0.5 | 11.7±1.3 | 11.4±0.7 | 11.2±1.1 | 10.8±0.7 | |
Ceruloplasmin (μM) | +DBBF | 1.53±1.27 | 1.48±0.91 | 1.60±1.32 | 1.73±1.45 | 1.87±1.57 | 1.71±1.75 | 1.62±1.60 |
Control | 2.47±1.81 | 2.29±1.71 | 2.37±1.84 | 2.35±1.81 | 2.37±1.71 | 2.35±1.81 | 2.41±1.75 | |
Transferrin iron (μM) | +DBBF | 11.40±2.03 | 17.14±3.55* | 17.50±3.43† | 18.16±3.69† | 18.68±3.56† | 20.03±4.54† | 18.79±5.66† |
Control | 10.74±4.09 | 9.55±3.01* | 9.47±3.52 | 9.46±3.59 | 9.23±3.26 | 8.56±2.71 | 8.08±2.30 | |
Erythrocyte radical (μM) | +DBBF | 0.083±0.061 | 0.064±0.026 | 0.071±0.033 | 0.089±0.031 | 0.047±0.026 | 0.058±0.062 | 0.051±0.046 |
Control | 0.053±0.012 | 0.049±0.017 | 0.041±0.007 | 0.088±0.075 | 0.046±0.015 | 0.046±0.011 | 0.045±0.018 | |
MetHb (μM) | +DBBF | 3.38±1.23 | 33.36±9.75*‡ | 29.09±8.08† | 23.17±8.11† | 15.17±7.00† | 8.21±3.02 | 6.48±2.95 |
Control | 2.69±1.05 | 2.49±0.82 | 2.56±0.80 | 2.63±0.90 | 2.41±0.71 | 2.64±0.55 | 2.61±0.81 |
*Immediate post transfusion value (t=5) significantly different from pre-transfusion value.
†Significantly different from control (two-way ANOVA with Bonferroni post test).
‡Significant linear trend (one-way ANOVA) from post transfusion (t=5) to the end of the study (t=180).