Figure 4. Antioxidant administration restores the antioxidant activity, EIC, and cell survival in Tlr4^–/– mice.

Tlr4^–/– mice were fed NAC, apocynin, or vehicle-only water and sacrificed at 3 months of age to determine total antioxidant activity in BAL (A); EIC in BAL (B); reduced GSH/oxidized GSH ratio in BAL (C); and TUNEL-positive cells (expressed as percent of total cells) in lung sections (D). *P < 0.05 versus WT; **P < 0.05 versus Tlr4^–/–. n = 4–5.