Figure 2.

Effects of the vehicle DMSO (1 ml kg⁻¹ s.c. twice a day for 3 days), TDZD-8 (0.1, 0.3 and 1.0 mg kg⁻¹ s.c. twice a day for 3 days) or SB 415286 (0.1, 0.33 and 1.0 mg kg⁻¹ s.c. twice a day for 3 days) on the change in body weight, expressed a % change in body weight immediately prior to challenge (upper panel) and the weight of the total colon segment expressed as g (lower panel). Measurements of body weight and the standard colonic segment weight were made 3 days after intracolonic challenge with TNBS. The values from the nonchallenged control group are also shown. Results are expressed as mean±s.e.m.; n=8–15; ^**P<0.01, ^***P<0.001 compared with the DMSO group.