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Effect of clodronate on the ApppI production evoked by risedronate (a), and risedronate on the metabolism of clodronate to AppCCl2p (b) in J774 macrophages. BPs were in free form. The molar amounts of ApppI and AppCCl2p were determined in cell extracts by using HPLC-ESI-MS as described under Methods. Mean±s.d., n=4–6. *P<0.05 compared with controls.
