Table 1.
Baroreflex parameters before and after microinjections of various pharmacological agents into the RVLM
| Treatment | Upper plateau (b.p.m.) | Lower plateau (b.p.m.) | Reflex range (b.p.m.) | MAP50 (mmHg) | GainMax (b.p.m. mmHg−1) | Pthr (mmHg) | Psat (mmHg) |
|---|---|---|---|---|---|---|---|
| Saline | |||||||
| Before | 390.1±7.3 | 330.2±9.6 | 59.9±2.8 | 98.6±1.6 | −2.4±0.2 | 86.8±2.3 | 110.5±1.4 |
| After | 390.6±8.8 | 328.1±10.7 | 62.5±5.0 | 99.5±1.6 | −2.4±0.3 | 85.5±2.9 | 113.5±2.7 |
| ADM (0.1 fmol) | |||||||
| Before | 390.8±3.7 | 331.3±7.6 | 59.4±5.9 | 98.1±3.0 | −2.1±0.4 | 83.5±6.5 | 112.6±1.3 |
| After | 367.3±11.3 | 323.4±9.1 | 43.9±6.8 | 102.1±3.0 | −1.2±0.2* | 85.7±5.0 | 118.5±2.8 |
| ADM (1 fmol) | |||||||
| Before | 390.8±5.9 | 332.7±4.2 | 58.0±2.4 | 99.1±1.5 | −2.4±0.3 | 87.1±2.5 | 111.1±0.8 |
| 1st hour after | 363.2±8.1* | 326.0±7.0 | 37.2±1.4** | 104.8±0.4** | −1.4±0.1** | 91.3±1.3 | 118.3±1.0** |
| 2nd hour after | 375.9±12.4 | 330.3±4.9 | 45.7±8.0 | 103.6±2.3 | −1.9±0.5 | 91.9±2.4 | 115.4±2.7 |
| 3rd hour after | 384.0±5.6 | 329.2±7.7 | 52.3±4.0 | 98.9±1.4 | −2.1±0.3 | 85.5±1.7 | 112.2±2.0 |
| ADM (1 fmol) outside of RVLM | |||||||
| Before | 389.9±10.3 | 330.9±8.9 | 59.0±1.8 | 99.0±1.4 | −2.4±0.3 | 86.0±2.6 | 112.1±0.7 |
| 1st hour after | 386.3±7.9 | 332.8±9.4 | 53.5±3.9 | 99.0±1.3 | −2.7±0.2 | 88.7±1.3 | 109.3±1.3 |
| 2nd hour after | 385.1±12.9 | 328.3±10.3 | 56.8±3.5 | 99.4±1.5 | −2.4±0.3 | 86.4±2.5 | 112.4±1.0 |
| 3rd hour after | 392.4±6.4 | 330.4±10.1 | 62.0±4.6 | 97.4±2.8 | −2.2±0.3 | 83.0±6.4 | 111.9±1.2 |
| ADM22–52 (0.1 fmol) | |||||||
| Before | 388.4±8.1 | 331.2±8.2 | 57.2±2.8 | 99.9±0.9 | −2.5±0.3 | 88.1±1.6 | 111.8±1.1 |
| After | 394.1±6.8 | 332.7±10.6 | 61.3±4.4 | 97.9±2.0 | −3.3±0.3 | 87.1±2.5 | 108.8±3.1 |
| ADM22–52 (1 fmol) | |||||||
| Before | 387.3±4.3 | 333.9±4.7 | 53.5±3.7 | 97.3±1.8 | −2.3±0.2 | 85.8±1.7 | 108.8±1.9 |
| After | 403.5±3.6* | 340.6±4.0 | 62.9±1.7 | 97.7±2.0 | −4.8±0.7* | 89.9±1.1 | 105.5±3.2 |
| ADM (1 fmol)+ ADM22–52 (0.1 fmol) | |||||||
| Before | 387.1±10.6 | 333.5±9.8 | 53.5±3.8 | 99.7±1.2 | −2.6±0.2 | 89.4±1.1 | 110.0±1.4 |
| After | 384.7±6.6 | 334.1±7.2 | 50.5±1.1 | 97.4±1.7 | −2.5±0.3 | 87.0±1.5 | 107.8±2.4 |
| H-89 (100 pmol) | |||||||
| Before | 388.5±9.4 | 332.5±8.6 | 55.9±2.8 | 99.0±1.3 | −2.5±0.3 | 87.4±2.3 | 110.6±1.7 |
| After | 387.6±11.3 | 332.9±8.1 | 54.7±4.0 | 97.3±1.2 | −2.3±0.4 | 84.9±2.1 | 109.6±2.3 |
| ADM (1 fmol)+H-89 (100 pmol) | |||||||
| Before | 387.9±10.0 | 334.4±9.5 | 53.6±4.5 | 98.0±1.6 | −2.4±0.3 | 86.8±2.5 | 109.3±1.7 |
| After | 379.1±12.0 | 330.1±8.6 | 49.0±5.2 | 100.5±2.0 | −1.9±0.2 | 86.7±2.3 | 114.3±2.1 |
Values are mean±s.e.m.
*
P<0.05 and
**
P<0.01 versus measurements before microinjections.