Table 2.
[3H]GR205171 and [3H]SP competition experiments on brain striatum of human (subject A) and gerbil
| |
pKi vs [3H]GR205171 |
pKi vs [3H]SP |
||
|---|---|---|---|---|
| Human | Gerbil | Human | Gerbil | |
| SP |
6.34±0.22a |
6.61±0.16a |
9.06±0.11 |
9.49±0.03 |
| |
(Hill slope=0.38±0.09) (n=4) |
(Hill slope=0.57±0.10) (n=3) |
(n=3) |
(n=3) |
| GR205171 |
10.50±0.09 |
10.79±0.02 |
10.65±0.10 |
10.48±0.10 |
| |
(n=3) |
(n=5) |
(n=4) |
(n=3) |
| L-733,060 |
9.81±0.14 |
9.94±0.15 |
9.71±0.15 |
9.77±0.04 |
| |
(n=4) |
(n=4) |
(n=4) |
(n=4) |
| Aprepitant |
10.11±0.04 |
10.34±0.07 |
10.11±0.20 |
10.06±0.12 |
| |
(n=4) |
(n=4) |
(n=4) |
(n=4) |
| NKP-608 |
9.31±0.13 |
9.34±0.28 |
9.09±0.14 |
9.30±0.23 |
| (n=3) | (n=3) | (n=3) | (n=3) | |
n represents the number of independent experiments. See Methods for experimental procedures.
a
pIC50 values.