Figure 4.

A summary of the total reductions in MAP produced by systemic injections of peroxynitrite (peroxynitrite, 1–20 μmol kg⁻¹, i.v.) in pentobarbital-anaesthetized rats before and after administration of saline (n=6) or L-penicillamine (L-PEN, 2 mmol kg⁻¹, i.v., n=6). Each value is the mean the total reductions in MAP (mmHg × s). The single s.e.m. values on each dose–response curve were derived from the repeated measures ANOVA (see Methods). ^*P<0.05, post-treatment versus Pre.