Table 2.

Resting haemodynamic parameters recorded before and after the administration of saline or L-penicillamine in rats that received peroxynitrite

Treatment	Parameter	Pre	Post	% Change
Saline	MAP, mmHg	117±5	114±5	−2±4
	MR, mmHg kHz−1	46±5	45±5	−2±5
	HQR, mmHg kHz−1	72±5	71±6	−1±4
L-Penicillamine	MAP, mmHg	118±3	137±4	+16±4*
	MR, mmHg kHz−1	43±8	54±9	+25±7*
	HQR, mmHg kHz−1	65±9	83±12	+33±10*

MAP=mean arterial blood pressure. MR=mesenteric vascular resistance. HQR=hindquarter vascular resistance.

All values are the mean±s.e.m. of the resting values recorded immediately before each of the five injections of peroxynitrite, prior to and after administration of saline or L-penicillamine (2 mmol kg⁻¹, i.v.). Post-treatment values were recorded between 25 and 50 min after administration of saline or L-PEN, the time over which the five injections of peroxynitrite were given. There were six rats in each group. ^*P<0.05, significant change from Pre.