Table 2.

Correlation between βAR-density, isoprenaline-stimulated and forskolin-stimulated adenylyl cyclase activity and cardiomyocyte apoptosis, cardiomyocyte hypertrophy and myocardial fibrosis

Correlation	CM apoptosis (TUNEL-positive CM mm−2)	CM hypertrophy (CSA, μm2)	Myocardial fibrosis (% of area)
Progression of heart failure
βAR-density	r=−0.6930	r=−0.5307	r=−0.4490
	P<0.0001	P=0.0026	P=0.0128
ISO-stimulated	r=−0.3678	r=−0.0651	r=−0.0029
AC-activity	P=0.0455	P=0.7327	P=0.9880
Forsk-stimulated	r=−0.4385	r=−0.2737	r=−0.2212
AC-activity	P=0.0154	P=0.1433	P=0.2402
Sabiporide treatment
βAR-density	r=0.0929	r=0.3587	r=−0.0925
	P=0.6810	P=0.1012	P=0.6822
ISO-stimulated	r=0.0742	r=0.1582	r=−0.0678
AC-activity	P=0.7429	P=0.4820	P=0.7644
Forsk-stimulated	r=−0.3805	r=0.1264	r=−0.1997
AC-activity	P=0.0807	P=0.5752	P=0.3728

AC=adenylyl cyclase-activity in pmol cAMP mg⁻¹ protein min⁻¹; βAR=β-adrenoceptor in fmol mg⁻¹ protein; CM=cardiomyocyte; ISO=isoprenaline; Forsk=forskolin.

r represents Pearson-correlation coefficient, P represents P-value.