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. 2006 Mar 20;148(2):173–190. doi: 10.1038/sj.bjp.0706716

Figure 10.

Figure 10

Concentration-dependent [Ca2+]i-mobilization responses (FLIPR) in HEK cells transiently expressing human UT receptor following exposure to (a) hU-II, (b) urantide and (c) GSK248451. BacMam-mediated (1–20% virus, v v−1) upregulation of human UT expression (Bmax increased ⩽12-fold from approximately 0.03–0.35 pmol mg−1 protein; Table 6) was associated with an increase in Emax for both urantide (intrinsic activity [α] elevated from 0.56–0.78 relative to hU-II) and GSK248451 (intrinsic activity [α] elevated from 0.07–0.18 relative to hU-II; Table 7).