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Concentration-dependent contraction of cat isolated (a) femoral artery and (b) thoracic aorta induced by hU-II (EC50s 0.3 and 1.3 nM, Emaxs 320 and 145% KCl, respectively; Table 4) and urantide (EC50s 1.7 and 93.6 nM, Emaxs 43 and 45% KCl, respectively; Table 4). Since urantide exhibited agonist activity in both cat isolated arteries (6–72-fold less potent than hU-II with relative intrinsic activities [α] of 0.13–0.31), Kb could not be determined (see Table 3).
