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Concentration-dependent contraction of monkey isolated (a) renal and (b) superior mesenteric artery induced by hU-II (EC50s 0.7 and 1.6 nM, Emaxs 148 and 107% KCl, respectively; Table 4) and urantide (EC50s 8.1 and 8.5 nM, Emaxs 97 and 76% KCl, respectively; Table 4). Since urantide exhibited agonist activity in both monkey isolated arteries (5–12-fold less potent than hU-II with relative intrinsic activities [α] of 0.66–0.71), Kb could not be determined (see Table 3).
